Study proves effectiveness of alternative test kits for COVID-19

Study proves effectiveness of alternative test kits for COVID-19



Reagents are the substances, compounds, primers, probes, enzymes and buffers that are needed in laboratory tests. Like the essential ingredients of a recipe, they are key to enabling a chemical reaction and ensuring the right end result – salt and butter, so to speak.

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Reagents are the substances, compounds, primers, probes, enzymes and buffers that are needed in laboratory tests. Like the essential ingredients of a recipe, they are key to enabling a chemical reaction and ensuring the right end result – salt and butter, so to speak.

“In a situation of increased demand like during the COVID-19 crisis, many laboratories could quickly find themselves in a situation in which they can no longer obtain reagents from their usual sources and are forced to switch to other reagent suppliers or other ad hoc suppliers change molecular diagnostic kits than the ones they are used to, ”says Adi Steinrigl, deputy head of the Molecular Biology department at AGES. “Laboratories performing real-time RT-PCR tests rely on trusted sources of reagents, usually in the form of a master mix or ready-to-use diagnostic kit solutions called ad hoc molecular diagnostic kits.”

A master mix is ​​a premixed solution that contains all of the components for a real-time RT-PCR reaction and is not sample specific, meaning the same reagents used to detect COVID-19 can also be used to detect other viruses. Ad hoc kits are for specific diseases and pathogens.

In ril 2020, the Joint FAO / IAEA Center for Nuclear Technology for Food and Agriculture, in collaboration with AGES, started a study to evaluate and compare eight master mixes and three ad hoc kits made by companies based in Austria, Germany , Jan, the Republic of Korea, the United Kingdom and the United States of America.

The study included the most common types of master mixes used and available in the international market, among the many molecular assays or tests marketed for the diagnosis of COVID-19. As of July 2021, 388 were listed by the Foundation for Innovative New Diagnostics.

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